The Single Best Strategy To Use For ceesdekker.net

The Single Best Strategy To Use For ceesdekker.net

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Utilizing single-molecule optical and AFM imaging and pressure-spectroscopy approaches, we find to unravel the mechanistic facets of the structure and dynamics of chromosomes. Our research pursuits contain:

You frequently get involved in conversations about science and faith. You've also penned many books on the topic. Don’t you feel that sooner or later We're going to know anything and that God’s role might be more than?

, Groningen scientists present the outcomes of their attempts to generate labs additional sustainable and supply guidelines for other labs. 

Nanofabrication of electrodes with sub-five nm spacing for transport experiments on one molecules and metal clusters

2015, discovery that condensin is a highly adaptable protein framework; and very first detection of DNA knots making use of nanopores

The coiled-coil of the human Rad50 DNA repair service protein includes specific segments of greater versatility

Many connected developments followed, in which our group proven diverse transistor variants for instance solitary-electron transistors at area temperature and intramolecular nanotube junctions that acted as rectifying diodes, and coupled many transistors into smaller evidence-of-theory electronic circuits.

Researching DNA loop extrusion by SMC proteins for chromosome architecture with solitary-molecule assays.

The rotors harness Power from the nanoscale drinking water and ion movement that may be produced by a static chemical or electrochemical possible gradient in the nanopore, which might be proven through a salt gradient or utilized voltage, respectively. These artificial nanoengines self-Arrange and operate autonomously in physiological disorders, suggesting strategies to constructing Electricity-transducing motors at nanoscale interfaces.

There was just one trouble though — we didn't notice any measurable electrical conduction from The one polymer molecules. We concluded that at The one-molecule amount, conducting polymers were being actually not such fantastic conductors, which was fairly disappointing. We Hence broadened our check out to try to discover a lot more promising molecules.

‘The idea that There is certainly this type of matter as a beginning, an enormous bang, is previously a fascinating signpost to consider that there was a creator. But much more normally, and on the basis of pure rationality, I also arrive in a Christian interpretation of reality. An atheistic worldview is really a naturalistic worldview: fundamentally, you'll find only atoms and organic forces that we could evaluate.

2006, ceesdekker very first demonstration of molecular sorting inside of a lab on a chip making use of biomotors; discovery of nanobubbles in stable-point out nanopores; and first estimate of electrokinetic Vitality conversion in a very nanofluidic channel

2005, discovery in the system of DNA uncoiling by topoisomerase enzymes; discovery of lengthy-array conformational changes in Mre11/DNA mend complexes; and first power measurements over a DNA molecule in a nanopore

Supercoiling-dependent DNA binding: quantitative modeling and applications to bulk and solitary-molecule experiments